Upward Spiral was published in 2015 by New Harbinger Publications. Alex Korb is a neuroscientist and researcher at UCLA whose work focuses on the neural circuits underlying mood, depression, and wellbeing. The book emerged from Korb’s recognition that the neuroscience of depression, which had advanced considerably in the preceding decade, was largely inaccessible to the people who most needed it: the millions of individuals living with low mood, chronic stress, or clinical depression who understood their experience as a personal failing or a permanent condition rather than as the result of identifiable, modifiable brain dynamics.
The book’s title captures its central argument with unusual precision. Depression operates as a downward spiral: each symptom makes the others worse. Poor sleep impairs mood regulation, which reduces motivation for exercise, which worsens sleep quality, which increases anxiety, which disrupts social connection, which deepens the cognitive distortions that make everything feel hopeless. The spiral is self-reinforcing, which is why depression feels so intractable, not because the underlying neurology is fixed, but because the circuits that produce depression actively resist the behaviours that would interrupt it. The upward spiral is the same dynamic running in reverse: small positive changes in any part of the system create cascading improvements throughout it, because the brain’s circuits are as good at amplifying positive change as they are at amplifying negative change.
Korb is writing for a specific reader: someone who is not in acute crisis and does not necessarily have a clinical diagnosis, but who experiences mood as something that happens to them rather than something they can influence, who has heard the advice to exercise more, sleep better, and connect with others but does not have the motivational resources to implement it. The book’s contribution is to make the neuroscience of these interventions comprehensible in a way that addresses the motivational paradox directly: you cannot change the conditions by waiting until you feel better, but you can change a single small thing right now, and that single small change will begin to shift the neurochemical conditions that make the next change slightly easier.









